PREY

HIF1A

HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
GO Process (34)
GO Function (13)
GO Component (7)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of HIF2 alpha nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

Steunou AL, Ducoux-Petit M, Lazar I, Monsarrat B, Erard M, Muller C, Clottes E, Schiltz O, Nieto L

Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that play a key role in cellular adaptation to hypoxia. HIF proteins are composed of an α subunit regulated by oxygen pressure (essentially HIF1α or HIF2α) and a constitutively expressed β subunit. These proteins are often overexpressed in cancer cells and HIF overexpression frequently correlates with poor prognosis, making HIF proteins promising therapeutic ... [more]

Mol. Cell Proteomics Dec. 28, 2012; 0(0); [Pubmed: 23275444]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
EPAS1 HIF1A
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2827829

Curated By

  • BioGRID