PHO85
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IGI, IMP]
- fungal-type cell wall organization [IGI]
- negative regulation of calcium-mediated signaling [IGI]
- negative regulation of glycogen biosynthetic process [IMP]
- negative regulation of macroautophagy [IMP]
- negative regulation of phosphate metabolic process [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of macroautophagy [IMP]
- protein phosphorylation [IDA]
- regulation of establishment or maintenance of cell polarity [IGI]
- regulation of protein localization [IDA]
- regulation of protein stability [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RGD1
Gene Ontology Biological Process
Gene Ontology Molecular Function- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
- Rho GTPase activator activity [IDA, IGI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA, IMP]
- phosphatidylinositol-3-phosphate binding [IDA, IMP]
- phosphatidylinositol-4,5-bisphosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA, IMP]
- phosphatidylinositol-5-phosphate binding [IDA, IMP]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity.
Cyclin-dependent kinases (Cdks) are key regulators of the cell division cycle. Pho85 is a multifunctional Cdk in budding yeast involved in aspects of metabolism, the cell cycle, cell polarity, and gene expression. Consistent with a broad spectrum of functions, Pho85 associates with a family of 10 cyclins and deletion of PHO85 causes a pleiotropic phenotype. Discovering the physiological substrates of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO85 RGD1 | Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene. | High | - | BioGRID | 350253 | |
| PHO85 RGD1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 450192 |
Curated By
- BioGRID