BAIT
CATSPER1
Catsper, KSper
cation channel, sperm associated 1
GO Process (10)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- calcium ion import [IBA]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IMP]
- fusion of sperm to egg plasma membrane [IMP]
- membrane depolarization during action potential [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cilium beat frequency involved in ciliary motility [IMP]
- regulation of ion transmembrane transport [IMP]
- sperm motility [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA2
70kDa, HSP70.2, HSP70A2, Hsp70-2
heat shock protein 2
GO Process (8)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- male meiosis [IMP]
- male meiosis I [IMP]
- negative regulation of inclusion body assembly [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein phosphorylation [IMP]
- protein refolding [ISO]
- spermatid development [IMP]
- synaptonemal complex disassembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CatSperbeta, a novel transmembrane protein in the CatSper channel complex.
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. We set out to identify proteins associating with CatSper that might help explain its unique role in spermatozoa. Using a transgenic approach, a CatSper1 complex was purified from ... [more]
J. Biol. Chem. Jun. 29, 2007; 282(26);18945-52 [Pubmed: 17478420]
Throughput
- Low Throughput
Curated By
- BioGRID