COL5A1
Gene Ontology Biological Process
- blood vessel development [IMP]
- cell adhesion [ISO]
- cell migration [ISO]
- collagen biosynthetic process [ISO]
- collagen fibril organization [IGI, IMP, ISO]
- extracellular fibril organization [ISO]
- eye morphogenesis [ISO]
- heart morphogenesis [IGI]
- integrin biosynthetic process [ISO]
- negative regulation of endodermal cell differentiation [ISO]
- regulation of cellular component organization [IMP]
- skin development [IMP, ISO]
- tendon development [IGI, IMP]
- wound healing, spreading of epidermal cells [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMAD2
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [IMP]
- cell fate commitment [IMP]
- common-partner SMAD protein phosphorylation [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- endoderm formation [IMP]
- gastrulation [IGI]
- heart development [IGI]
- in utero embryonic development [IGI, IMP]
- insulin secretion [IGI]
- intracellular signal transduction [IDA, ISO]
- lung development [IGI]
- mesoderm formation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nodal signaling pathway [ISO]
- organ growth [IGI]
- palate development [IMP]
- pancreas development [IGI]
- paraxial mesoderm morphogenesis [IMP]
- pattern specification process [IGI]
- pericardium development [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- post-embryonic development [IGI]
- protein phosphorylation [IDA, ISS]
- regulation of binding [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- response to cholesterol [ISO]
- response to glucose [IGI]
- signal transduction involved in regulation of gene expression [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, IGI, ISO]
- zygotic specification of dorsal/ventral axis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of Smads with collagen types I, III, and V.
Ontogenesis of the mammalian orofacial region is controlled by numerous developmental signals, including those initiated by the transforming growth factors beta (TGFbetas). Targeted deletion of the genes encoding several of the TGFbetas in mice has been shown to result in clefts of the secondary palate. Members of the TGFbeta family of growth factors utilize intracellular Smads as signal transducers. Smads ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID