ABCD1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid beta-oxidation [IDA, IGI]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- linoleic acid metabolic process [TAS]
- long-chain fatty acid catabolic process [IGI]
- peroxisomal long-chain fatty acid import [IGI]
- peroxisomal membrane transport [NAS]
- peroxisome organization [IDA, NAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty acid catabolic process [IDA, IGI]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
Gene Ontology Cellular Component
SLC27A2
Gene Ontology Biological Process
- bile acid biosynthetic process [IDA, TAS]
- bile acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid alpha-oxidation [IDA, TAS]
- fatty acid beta-oxidation [IDA]
- long-chain fatty acid import [IDA]
- long-chain fatty acid metabolic process [IDA]
- methyl-branched fatty acid metabolic process [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix.
The beta-oxidation of fatty acids in peroxisomes produces hydrogen peroxide (H2O2), a toxic metabolite, as a bi-product. Fatty acids beta-oxidation activity is deficient in X-linked adrenoleukodystrophy (X-ALD) because of mutation in ALD-gene resulting in loss of very long chain acyl-CoA synthetase (VLCS) activity. It is also affected in disease with catalase negative peroxisomes as a result of inactivation by H2O2. ... [more]
Throughput
- Low Throughput
Ontology Terms
- tissue: liver (BTO:0000759)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC27A2 ABCD1 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 820595 |
Curated By
- BioGRID