RAD51
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RSP5
Gene Ontology Biological Process
- cellular response to UV [IMP]
- chromatin assembly or disassembly [IMP]
- late endosome to vacuole transport via multivesicular body sorting pathway [IMP, IPI]
- mitochondrion organization [IGI, IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IPI]
- protein autoubiquitination [IGI]
- protein monoubiquitination [IDA, IGI, IMP]
- protein polyubiquitination [IDA, IMP]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of actin cytoskeleton organization [IGI]
- regulation of dolichol biosynthetic process [IGI, IMP]
- regulation of ergosterol biosynthetic process [IGI, IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of mRNA export from nucleus [IMP, IPI]
- regulation of multivesicular body size [IMP]
- regulation of nitrogen utilization [IGI]
- regulation of phosphate metabolic process [IGI]
- regulation of protein localization [IMP, IPI]
- regulation of rRNA processing [IMP]
- regulation of ribosomal large subunit export from nucleus [IMP]
- regulation of tRNA export from nucleus [IMP]
- regulation of tRNA processing [IMP]
- regulation of ubiquinone biosynthetic process [IGI, IMP]
- response to drug [IMP, IPI]
- ribophagy [IGI]
- ubiquitin-dependent endocytosis [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork.
The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions between tumor-specific somatic mutations and a second-site target gene. One hallmark of most cancers that can be exploited by chemotherapies is chromosome instability (CIN). Because chromosome replication, maintenance, and segregation represent conserved and cell-essential processes, they can be modeled ... [more]
Quantitative Score
- 0.000674625 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- SGA analysis for synthetic lethal interactions between mutations whose human orthologs are found to be mutated in cancers, and the deletion mutant collection, where the interaction probability P < 0.05
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RSP5 RAD51 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.6814 | BioGRID | 218114 | |
| RAD51 RSP5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.3473 | BioGRID | 311461 |
Curated By
- BioGRID