PTEN
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- activation of mitotic anaphase-promoting complex activity [IDA]
- apoptotic process [ISS]
- brain morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell migration [ISS]
- cell proliferation [TAS]
- central nervous system development [ISS]
- central nervous system myelin maintenance [ISS]
- central nervous system neuron axonogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- dentate gyrus development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- innate immune response [TAS]
- inositol phosphate dephosphorylation [IDA]
- inositol phosphate metabolic process [TAS]
- learning or memory [ISS]
- locomotor rhythm [ISS]
- locomotory behavior [ISS]
- multicellular organismal response to stress [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell size [ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- negative regulation of dendritic spine morphogenesis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of organ growth [ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [TAS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of synaptic vesicle clustering [ISS]
- neuron-neuron synaptic transmission [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of cell proliferation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- postsynaptic density assembly [ISS]
- prepulse inhibition [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [IDA, TAS]
- protein kinase B signaling [ISS]
- protein stabilization [IDA]
- regulation of cellular component size [ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of neuron projection development [ISS]
- regulation of protein stability [IMP]
- rhythmic synaptic transmission [ISS]
- small molecule metabolic process [TAS]
- social behavior [ISS]
- synapse assembly [ISS]
- synapse maturation [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
Gene Ontology Cellular Component
CDC27
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- cell proliferation [TAS]
- metaphase/anaphase transition of mitotic cell cycle [IMP]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K11-linked ubiquitination [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTEN CDC27 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| PTEN CDC27 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CDC27 PTEN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID