BAIT
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSF1R
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
colony stimulating factor 1 receptor
GO Process (31)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cell-cell junction maintenance [IMP]
- cellular response to cytokine stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cytokine-mediated signaling pathway [IMP]
- hemopoiesis [IMP]
- inflammatory response [TAS]
- macrophage differentiation [TAS]
- mammary gland duct morphogenesis [TAS]
- monocyte differentiation [TAS]
- multicellular organismal development [TAS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [ISS]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell motility [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemokine secretion [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of bone resorption [ISS]
- regulation of cell shape [IMP]
- ruffle organization [ISS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine, but determinants of client recognition by HSP90 have remained frustratingly elusive. We systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37. Unexpectedly, many more kinases than ... [more]
Cell Aug. 31, 2012; 150(5);987-1001 [Pubmed: 22939624]
Throughput
- Low Throughput
Curated By
- BioGRID