BAIT
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACVR1B
ACTRIB, ACVRLK4, ALK4, SKR2
activin A receptor, type IB
GO Process (14)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- activin receptor signaling pathway [IDA, IMP]
- extrinsic apoptotic signaling pathway [IMP]
- negative regulation of cell growth [IDA]
- nodal signaling pathway [IGI]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of trophoblast cell migration [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine, but determinants of client recognition by HSP90 have remained frustratingly elusive. We systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37. Unexpectedly, many more kinases than ... [more]
Cell Aug. 31, 2012; 150(5);987-1001 [Pubmed: 22939624]
Throughput
- Low Throughput
Curated By
- BioGRID