BAIT
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IRAK3
ASRT5, IRAKM
interleukin-1 receptor-associated kinase 3
GO Process (24)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cytokine-mediated signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of cytokine-mediated signaling pathway [IC]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-12 production [IMP, ISS]
- negative regulation of interleukin-6 production [IMP, ISS]
- negative regulation of macrophage cytokine production [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of toll-like receptor signaling pathway [ISS]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of macrophage tolerance induction [ISS]
- protein phosphorylation [IDA]
- regulation of protein complex disassembly [ISS]
- response to exogenous dsRNA [ISS]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [ISS]
- response to peptidoglycan [ISS]
- response to virus [IC]
- toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
HSP90 is a molecular chaperone that associates with numerous substrate proteins called clients. It plays many important roles in human biology and medicine, but determinants of client recognition by HSP90 have remained frustratingly elusive. We systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37. Unexpectedly, many more kinases than ... [more]
Cell Aug. 31, 2012; 150(5);987-1001 [Pubmed: 22939624]
Throughput
- High Throughput
Curated By
- BioGRID