BAIT
FCHO2
5832424M12Rik, AA387320
FCH domain only 2
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYNJ1
synaptojanin 1
GO Process (14)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- brain development [IEP]
- inositol phosphate dephosphorylation [ISO, ISS]
- learning [ISO]
- neurotransmitter transport [ISO, ISS]
- phosphatidylinositol dephosphorylation [ISO, ISS]
- phosphatidylinositol metabolic process [ISO, ISS]
- positive regulation of gliogenesis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- response to cytokine [IMP]
- response to retinoic acid [IMP]
- synaptic vesicle endocytosis [ISO, ISS]
- synaptic vesicle priming [ISO, ISS]
- synaptic vesicle transport [ISO, ISS]
- synaptic vesicle uncoating [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FCHo proteins are nucleators of clathrin-mediated endocytosis.
Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors destined for internalization. However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHo1/2) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. ... [more]
Science Jun. 04, 2010; 328(5983);1281-4 [Pubmed: 20448150]
Throughput
- Low Throughput
Additional Notes
- figure 2.
- figure S6.
Curated By
- BioGRID