BAIT
FCHO2
5832424M12Rik, AA387320
FCH domain only 2
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TFAP2B
Tcfap2b
transcription factor AP-2 beta
GO Process (43)
GO Function (17)
GO Component (2)
Gene Ontology Biological Process
- anatomical structure development [IBA]
- aorta morphogenesis [ISO, ISS]
- apoptotic process [ISO]
- calcium ion homeostasis [ISO, ISS]
- cellular ammonia homeostasis [ISO, ISS]
- cellular creatinine homeostasis [ISO, ISS]
- cellular urea homeostasis [ISO, ISS]
- collecting duct development [ISO, ISS]
- distal tubule development [ISO, ISS]
- ductus arteriosus closure [ISO, ISS]
- fat cell differentiation [ISO]
- forelimb morphogenesis [ISO, ISS]
- glucose homeostasis [ISO, ISS]
- glucose metabolic process [ISO, ISS]
- hindlimb morphogenesis [ISO, ISS]
- kidney development [ISO, ISS]
- magnesium ion homeostasis [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- phosphate ion homeostasis [ISO, ISS]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of neuron apoptotic process [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of urine volume [ISO, ISS]
- potassium ion homeostasis [ISO, ISS]
- regulation of BMP signaling pathway [ISO, ISS]
- regulation of cell differentiation [ISO, ISS]
- regulation of cell proliferation [IBA]
- regulation of insulin secretion [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [ISO, ISS]
- renal water homeostasis [ISO, ISS]
- response to drug [IEP]
- response to lithium ion [IEP]
- retina layer formation [ISO]
- sodium ion homeostasis [ISO, ISS]
- sympathetic nervous system development [ISO, ISS]
- transcription from RNA polymerase II promoter [ISO, ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO, ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription coactivator activity [ISO, ISS]
- RNA polymerase II transcription corepressor activity [ISO, ISS]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO, ISS]
- enhancer sequence-specific DNA binding [ISO]
- protein dimerization activity [ISO, ISS]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO, ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription corepressor activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO, ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription coactivator activity [ISO, ISS]
- RNA polymerase II transcription corepressor activity [ISO, ISS]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO, ISS]
- enhancer sequence-specific DNA binding [ISO]
- protein dimerization activity [ISO, ISS]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [ISO, ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription corepressor activity [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FCHo proteins are nucleators of clathrin-mediated endocytosis.
Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors destined for internalization. However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHo1/2) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. ... [more]
Science Jun. 04, 2010; 328(5983);1281-4 [Pubmed: 20448150]
Throughput
- Low Throughput
Additional Notes
- figure S6.
Curated By
- BioGRID