BAIT

FCHO2

5832424M12Rik, AA387320
FCH domain only 2
Mus musculus
PREY

ITSN2

PRO2015, SH3D1B, SH3P18, SWA, SWAP
intersectin 2
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FCHo proteins are nucleators of clathrin-mediated endocytosis.

Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT

Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors destined for internalization. However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology domain-only proteins 1 and 2 (FCHo1/2) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV formation. ... [more]

Science Jun. 04, 2010; 328(5983);1281-4 [Pubmed: 20448150]

Throughput

  • Low Throughput

Additional Notes

  • figure S6.

Curated By

  • BioGRID