BAIT
RRD1
YPA1, peptidylprolyl isomerase RRD1, L000004483, YIL153W
Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
SWE1
WEE1, tyrosine protein kinase SWE1, L000002248, YJL187C
Protein kinase that regulates the G2/M transition; regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; phosphorylates conserved tyrosine residue in N-terminus of Hsp90 in cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; homolog of S. pombe Wee1p; potential Cdc28p substrate
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- G2 cell size control checkpoint [IEP, IMP]
- G2/M transition of mitotic cell cycle [IDA, IMP, ISS]
- cytokinesis after mitosis checkpoint [IDA, IEP, IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- protein phosphorylation [IDA]
- re-entry into mitotic cell cycle [IGI]
- regulation of cell size [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of meiosis [IEP, IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.
The p21-activated kinases Ste20p and Cla4p carry out undefined functions that are essential for viability during budding in Saccharomyces cerevisiae. To gain insight into the roles of Ste20p, we have used a synthetic lethal mutant screen to identify additional genes that are required in the absence of Cla4p. Altogether, we identified 65 genes, including genes with roles in cell polarity, ... [more]
Mol. Biol. Cell Apr. 01, 2003; 14(4);1501-16 [Pubmed: 12686605]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- in cla4 background
Curated By
- BioGRID