BAIT
NAMPT
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
nicotinamide phosphoribosyltransferase
GO Process (13)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- NAD metabolic process [TAS]
- adipose tissue development [IDA]
- cell-cell signaling [TAS]
- circadian regulation of gene expression [ISS]
- insulin receptor signaling pathway [IDA]
- nicotinamide metabolic process [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADORA2A
A2aR, ADORA2, RDC8
adenosine A2a receptor
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- apoptotic process [TAS]
- blood circulation [TAS]
- blood coagulation [TAS]
- cAMP biosynthetic process [TAS]
- cell-cell signaling [TAS]
- cellular defense response [TAS]
- central nervous system development [TAS]
- inflammatory response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phagocytosis [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- sensory perception [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury.
Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated. ND1, ferritin and IFITM3 are involved in oxidative stress ... [more]
FEBS Lett. Jun. 11, 2008; 582(13);1802-8 [Pubmed: 18486613]
Throughput
- Low Throughput
Curated By
- BioGRID