PCSK9
Gene Ontology Biological Process
- cellular response to insulin stimulus [ISS]
- cellular response to starvation [ISS]
- cholesterol homeostasis [IMP]
- kidney development [ISS]
- liver development [ISS]
- low-density lipoprotein particle receptor catabolic process [IDA]
- lysosomal transport [IDA]
- negative regulation of low-density lipoprotein particle clearance [IDA]
- negative regulation of receptor recycling [IDA]
- neurogenesis [ISS]
- neuron differentiation [ISS]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of receptor internalization [IDA]
- protein autoprocessing [IDA]
- proteolysis [IBA]
- regulation of neuron apoptotic process [ISS]
- regulation of receptor activity [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
- apolipoprotein binding [ISS]
- apolipoprotein receptor binding [IDA]
- low-density lipoprotein particle binding [ISS]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein self-association [IDA]
- serine-type endopeptidase activity [IDA]
- sodium channel inhibitor activity [IDA]
- very-low-density lipoprotein particle binding [ISS]
- very-low-density lipoprotein particle receptor binding [IDA]
Gene Ontology Cellular Component
BACE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
We have recently identified a new form of post-translational regulation of BACE1 (beta-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide (Abeta). Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi intermediate compartment (ER/ERGIC). The acetylated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PCSK9 BACE1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID