CYP2C8
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- drug metabolic process [IDA]
- epoxygenase P450 pathway [IBA, TAS]
- exogenous drug catabolic process [IDA]
- omega-hydroxylase P450 pathway [TAS]
- organic acid metabolic process [IDA]
- oxidation-reduction process [IDA]
- oxidative demethylation [IDA]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IBA, TAS]
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
PGRMC1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Progesterone receptor membrane component 1 inhibits the activity of drug-metabolizing cytochromes P450 and binds to cytochrome P450 reductase.
Progesterone receptor membrane component 1 (PGRMC1) has been shown to interact with several cytochromes P450 (P450s) and to activate enzymatic activity of P450s involved in sterol biosynthesis. We analyzed the interactions of PGRMC1 with the drug-metabolizing P450s, CYP2C2, CYP2C8, and CYP3A4, in transfected cells. Based on coimmunoprecipitation assays, PGRMC1 bound efficiently to all three P450s, and binding to the catalytic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID