BAIT

DAB2

DOC-2, DOC2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
GO Process (23)
GO Function (5)
GO Component (9)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.

Mulkearns EE, Cooper JA

Clathrin-mediated endocytosis regulates the internalization of many nutrient and signaling receptors. Clathrin and endocytic accessory proteins are recruited to receptors by specific adaptors. The adaptor Disabled-2 (Dab2) recruits its cargoes, including the low-density lipoprotein receptor (LDLR), and mediates endocytosis, even when the major adaptor protein AP2 is depleted. We hypothesized that the accessory proteins normally recruited by AP2 may be ... [more]

Mol. Biol. Cell Apr. 01, 2012; 23(7);1330-42 [Pubmed: 22323290]

Throughput

  • Low Throughput

Additional Notes

  • figure 1,

Curated By

  • BioGRID