BAIT
RHEB
RHEB2
Ras homolog enriched in brain
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRAF2
AI325259, RP23-464C2.1
TNF receptor-associated factor 2
GO Process (24)
GO Function (13)
GO Component (9)
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular protein complex assembly [IDA]
- cellular response to nitric oxide [IMP]
- negative regulation of apoptotic process [NAS]
- negative regulation of glial cell apoptotic process [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- programmed necrotic cell death [IMP]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein catabolic process [IMP]
- protein complex assembly [ISO]
- protein heterooligomerization [ISO]
- protein homotrimerization [ISO]
- regulation of JNK cascade [IDA]
- regulation of apoptotic process [ISO]
- regulation of immunoglobulin secretion [IMP]
- signal transduction [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR ... [more]
Mol. Cell Proteomics Jul. 01, 2010; 9(7);1578-93 [Pubmed: 20368287]
Throughput
- High Throughput
Curated By
- BioGRID