SYK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adaptive immune response [IBA, ISS]
- blood coagulation [TAS]
- blood vessel morphogenesis [ISS]
- cell proliferation [TAS]
- cellular response to molecule of fungal origin [ISS]
- defense response to bacterium [ISS]
- inflammatory response [IBA]
- innate immune response [IBA, ISS, TAS]
- integrin-mediated signaling pathway [ISS, NAS]
- leukocyte activation involved in immune response [ISS]
- leukocyte cell-cell adhesion [IDA]
- lymph vessel development [ISS]
- macrophage activation involved in immune response [IBA, ISS]
- neutrophil activation involved in immune response [IBA, ISS]
- neutrophil chemotaxis [IDA]
- organ morphogenesis [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- platelet activation [TAS]
- positive regulation of B cell differentiation [IBA]
- positive regulation of alpha-beta T cell proliferation [IBA]
- positive regulation of bone resorption [ISS]
- positive regulation of cell adhesion mediated by integrin [IBA, ISS]
- positive regulation of mast cell degranulation [IBA]
- protein phosphorylation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of arachidonic acid secretion [ISS]
- regulation of neutrophil degranulation [ISS]
- regulation of phagocytosis [ISS]
- regulation of platelet activation [ISS]
- regulation of platelet aggregation [IBA, ISS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of superoxide anion generation [ISS]
- serotonin secretion by platelet [ISS]
- transcription factor import into nucleus [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERBB4
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac muscle tissue regeneration [ISS]
- cell migration [IDA]
- cell proliferation [TAS]
- central nervous system morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- lactation [IMP]
- mammary gland alveolus development [ISS]
- mammary gland epithelial cell differentiation [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- nervous system development [ISS]
- neural crest cell migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- olfactory bulb interneuron differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of STAT protein import into nucleus [IMP]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell migration [ISS]
- signal transduction [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate one of the most well-studied signalling networks, there is not yet a genome-wide view of even the earliest step in this pathway: recruitment of proteins to the activated receptors. Here we use protein microarrays comprising virtually every Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain encoded ... [more]
Throughput
- High Throughput
Additional Notes
- interaction detected by probing protein array with labeled peptides
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ERBB4 SYK | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | 0.59 | BioGRID | 2847108 |
Curated By
- BioGRID