BAIT

MLH1

COCA2, FCC2, HNPCC, HNPCC2, hMLH1
mutL homolog 1
Fanconi Anemia Project
Glioblastoma Project
Homo sapiens
PREY

EXOC3

SEC6, SEC6L1, Sec6p
exocyst complex component 3
GO Process (4)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.

Brieger A, Adryan B, Wolpert F, Passmann S, Zeuzem S, Trojan J

The involvement of MLH1 in several mismatch repair-independent cellular processes has been reported. In an attempt to gain further insight into the protein's cellular functions, we screened for novel interacting partners of MLH1 utilizing a bacterial two-hybrid system. Numerous unknown interacting proteins were identified, suggesting novel biological roles of MLH1. The network of MLH1 and its partner proteins involves a ... [more]

Proteomics Sep. 01, 2010; 10(18);3343-55 [Pubmed: 20706999]

Throughput

  • Low Throughput

Curated By

  • BioGRID