BAIT
PPP5C
PP5, PPP5, PPT
protein phosphatase 5, catalytic subunit
GO Process (4)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHORDC1
1110001O09Rik, AA409036, Chp-1, morgana
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
GO Process (4)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
Mammals have two cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones, Chp-1 and melusin, which are homologs of plant Rar1. It has been shown previously that Rar1 CHORD directly interacts with ADP bound to the nucleotide pocket of Hsp90. Here, we report that ADP and ATP can bind to Hsp90 cochaperones Chp-1 and PP5, inducing their conformational changes. Furthermore, we demonstrate ... [more]
J. Biol. Chem. Jan. 04, 2013; 288(1);215-22 [Pubmed: 23184943]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHORDC1 PPP5C | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 835871 |
Curated By
- BioGRID