BAIT

METTL18

AsTP2, C1orf156, HPM1, RP1-117P20.4
methyltransferase like 18
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TCP1

CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha
t-complex 1
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M, Coulombe B

Methylation is a post-translational modification that can affect numerous features of proteins, notably cellular localization, turnover, activity, and molecular interactions. Recent genome-wide analyses have considerably extended the list of human genes encoding putative methyltransferases. Studies on protein methyltransferases have revealed that the regulatory function of methylation is not limited to epigenetics, with many non-histone substrates now being discovered. We present ... [more]

PLoS Genet. Jan. 01, 2013; 9(1);e1003210 [Pubmed: 23349634]

Quantitative Score

  • 0.077372949 [Confidence Score]

Throughput

  • High Throughput|Low Throughput

Ontology Terms

  • cell line: hek-293 cell (BTO:0000007)

Additional Notes

  • Included protein pairs with FDR score < 0.1
  • figure 2, table S1.

Curated By

  • BioGRID