An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.

Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, Huang CY

The increasing use of high-throughput and large-scale bioinformatics-based studies has generated a massive amount of data stored in a number of different databases. The major need now is to explore this disparate data to find biologically relevant interactions and pathways. Thus, in the post-genomic era, there is clearly a need for the development of algorithms that can accurately predict novel ... [more]

Mol. Cell Proteomics Jan. 01, 2004; 3(1);93-104 [Pubmed: 14602875]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

AURKA

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone serine kinase activity [IBA]protein binding [IPI]protein kinase activity [IDA]protein kinase binding [IPI]protein serine/threonine kinase activity [EXP]protein serine/threonine/tyrosine kinase activity [TAS]

Gene Ontology Cellular Component

NUF2