BAIT

ZWINT

HZwint-1, KNTC2AP, ZWINT1
ZW10 interacting kinetochore protein
GO Process (4)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SMG5

EST1B, LPTS-RP1, LPTSRP1, SMG-5, RP11-54H19.7
SMG5 nonsense mediated mRNA decay factor
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW

The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. ZW10 and Rod play an essential role in this checkpoint. We show that in mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part ... [more]

J. Cell Biol. Apr. 11, 2005; 169(1);49-60 [Pubmed: 15824131]

Throughput

  • Low Throughput

Curated By

  • BioGRID