BAIT
TTI1
FMP47, YKL033W
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
GO Process (0)
GO Function (0)
GO Component (3)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
BCK1
LAS3, SAP3, SLK1, SSP31, mitogen-activated protein kinase kinase kinase BCK1, L000000162, YJL095W
MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase
GO Process (8)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- endoplasmic reticulum unfolded protein response [IMP]
- establishment of cell polarity [IMP]
- intracellular signal transduction [IMP]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, TAS]
- regulation of fungal-type cell wall organization [IGI, IMP]
- response to acidic pH [IMP]
- response to nutrient [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components.
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and ... [more]
PLoS Genet. Apr. 01, 2011; 7(4);e1002057 [Pubmed: 21552543]
Quantitative Score
- -0.717152667 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- interaction score < -0.3, p-value > 0.05; tti1-1 allele
Curated By
- BioGRID