BAIT
TTI2
YJR136C
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
TOR2
DRR2, phosphatidylinositol kinase-related protein kinase TOR2, L000002323, YKL203C
PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
GO Process (12)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- TOR signaling [IC, IMP]
- actin filament reorganization involved in cell cycle [TAS]
- cytoskeleton organization [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- negative regulation of autophagy [IGI]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [IGI, IMP]
- positive regulation of Rho protein signal transduction [IGI, IMP]
- positive regulation of endocytosis [IMP]
- regulation of cell cycle [TAS]
- regulation of cell growth [TAS]
- ribosome biogenesis [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components.
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and ... [more]
PLoS Genet. Apr. 01, 2011; 7(4);e1002057 [Pubmed: 21552543]
Quantitative Score
- -0.650484356 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- colony size (APO:0000063)
Additional Notes
- interaction score < -0.3, p-value > 0.05; tti1-1 allele
Curated By
- BioGRID