BAIT
TTI2
YJR136C
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
RSP5
MDP1, MUT2, NPI1, SMM1, UBY1, NEDD4 family E3 ubiquitin-protein ligase, L000001054, L000001779, L000001220, YER125W
E3 ubiquitin ligase of NEDD4 family; regulates many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, ribosome stability; mutant tolerates aneuploidy; autoubiquitinates; ubiquitinates Sec23p and Sna3p; deubiquitinated by Ubp2p; activity regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; human homolog implicated in Liddle syndrome
GO Process (33)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- cellular response to UV [IMP]
- chromatin assembly or disassembly [IMP]
- late endosome to vacuole transport via multivesicular body sorting pathway [IMP, IPI]
- mitochondrion organization [IGI, IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IPI]
- protein autoubiquitination [IGI]
- protein monoubiquitination [IDA, IGI, IMP]
- protein polyubiquitination [IDA, IMP]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of actin cytoskeleton organization [IGI]
- regulation of dolichol biosynthetic process [IGI, IMP]
- regulation of ergosterol biosynthetic process [IGI, IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of mRNA export from nucleus [IMP, IPI]
- regulation of multivesicular body size [IMP]
- regulation of nitrogen utilization [IGI]
- regulation of phosphate metabolic process [IGI]
- regulation of protein localization [IMP, IPI]
- regulation of rRNA processing [IMP]
- regulation of ribosomal large subunit export from nucleus [IMP]
- regulation of tRNA export from nucleus [IMP]
- regulation of tRNA processing [IMP]
- regulation of ubiquinone biosynthetic process [IGI, IMP]
- response to drug [IMP, IPI]
- ribophagy [IGI]
- ubiquitin-dependent endocytosis [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components.
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and ... [more]
PLoS Genet. Apr. 01, 2011; 7(4);e1002057 [Pubmed: 21552543]
Quantitative Score
- -0.619624308 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- interaction score < -0.3, p-value > 0.05; tti1-1 allele
Curated By
- BioGRID