BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PTPRC
CD45, L-CA, Lca, RT7, T200
protein tyrosine phosphatase, receptor type, C
GO Process (47)
GO Function (7)
GO Component (12)
Gene Ontology Biological Process
- B cell differentiation [ISO]
- B cell proliferation [ISO, ISS]
- B cell receptor signaling pathway [ISO, ISS]
- T cell differentiation [ISO, ISS]
- T cell proliferation [ISO]
- T cell receptor signaling pathway [ISO, ISS]
- activation of MAPK activity [ISO]
- bone marrow development [ISO]
- cell cycle phase transition [ISO]
- defense response to virus [ISO, ISS]
- dephosphorylation [ISO, ISS]
- hematopoietic progenitor cell differentiation [ISO]
- heterotypic cell-cell adhesion [ISO]
- immunoglobulin biosynthetic process [ISO]
- leukocyte cell-cell adhesion [ISO]
- negative regulation of T cell mediated cytotoxicity [ISO, ISS]
- negative regulation of cell adhesion involved in substrate-bound cell migration [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO, ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein autophosphorylation [ISO]
- negative regulation of protein kinase activity [ISO, ISS]
- negative thymic T cell selection [ISO]
- peptidyl-tyrosine dephosphorylation [ISO, ISS, TAS]
- positive regulation of B cell proliferation [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of T cell differentiation [ISO]
- positive regulation of T cell mediated cytotoxicity [ISO]
- positive regulation of T cell mediated immunity [ISO]
- positive regulation of T cell proliferation [ISO, ISS]
- positive regulation of alpha-beta T cell proliferation [ISO]
- positive regulation of antigen receptor-mediated signaling pathway [ISO, ISS]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of gamma-delta T cell differentiation [ISO]
- positive regulation of hematopoietic stem cell migration [ISO]
- positive regulation of humoral immune response mediated by circulating immunoglobulin [ISO]
- positive regulation of isotype switching to IgG isotypes [ISO]
- positive regulation of stem cell proliferation [ISO]
- positive thymic T cell selection [ISO]
- protein dephosphorylation [ISO, ISS, TAS]
- regulation of B cell differentiation [ISO]
- regulation of B cell receptor signaling pathway [ISO]
- regulation of cell cycle [ISO, ISS]
- regulation of extrinsic apoptotic signaling pathway [ISO]
- regulation of humoral immune response mediated by circulating immunoglobulin [ISO]
- release of sequestered calcium ion into cytosol [ISO, ISS]
- response to gamma radiation [IDA]
- stem cell development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell periphery [ISO]
- cell surface [IDA]
- cytoplasmic side of plasma membrane [TAS]
- cytosol [ISO]
- external side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO, ISS]
- integral component of membrane [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- membrane [ISO]
- plasma membrane [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID