PRMT2
Gene Ontology Biological Process
- developmental cell growth [ISS]
- histone arginine methylation [IBA]
- histone methylation [IDA, ISS]
- negative regulation of G1/S transition of mitotic cell cycle [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein methylation [TAS]
- regulation of androgen receptor signaling pathway [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
- androgen receptor binding [IPI]
- estrogen receptor binding [IDA, IPI]
- histone methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IBA, ISS]
- peroxisome proliferator activated receptor binding [IPI]
- progesterone receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein-arginine N-methyltransferase activity [ISS]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [IPI]
- signal transducer activity [TAS]
- thyroid hormone receptor binding [IPI]
- transcription coactivator activity [IDA]
Gene Ontology Cellular Component
HNRNPA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Physical and functional interactions between hnRNP K and PRMT family proteins.
The mechanism underlying the protein-protein interaction of hnRNP K and PRMT family proteins is unclear. We examined and confirmed the arginine methylation of hnRNP K protein by PRMT1, not CARM1, via their direct binding. We also studied hnRNP K protein complexes containing CARM1, as well as PRMT1, using co-immunoprecipitation analysis. PRMT family proteins might be involved in the regulation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID