BAIT
PLK3
CNK, FNK, PRK, RP11-269F19.6
polo-like kinase 3
GO Process (19)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- G2/M transition of mitotic cell cycle [TAS]
- Golgi disassembly [IDA]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- cytoplasmic microtubule organization [IMP]
- endomitotic cell cycle [TAS]
- mitotic G1/S transition checkpoint [ISS]
- mitotic cell cycle checkpoint [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [IDA]
- protein kinase B signaling [ISS]
- regulation of cell division [IDA]
- regulation of cytokinesis [IMP, TAS]
- response to osmotic stress [IDA]
- response to radiation [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CENPU
CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
centromere protein U
GO Process (3)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Polo-like kinase-1 (Plk1) has a pivotal role in cell proliferation and is considered a potential target for anticancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 forms a phosphoepitope binding module for protein-protein interaction. Here, we report the identification of minimal phosphopeptides that specifically interact with the PBD of human PLK1, but not those of the closely related PLK2 and ... [more]
Nat. Struct. Mol. Biol. Aug. 01, 2009; 16(8);876-82 [Pubmed: 19597481]
Throughput
- Low Throughput
Curated By
- BioGRID