CACNA1B
Gene Ontology Biological Process
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IBA, IMP]
- calcium ion transport [IMP, ISO]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- neurotransmitter secretion [IMP]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of blood pressure [IMP]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [IMP]
- regulation of ion transmembrane transport [IMP]
- response to organic cyclic compound [ISO]
- response to pain [IMP]
- response to testosterone [ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CACNB2
Gene Ontology Biological Process
- calcium ion import [ISO]
- calcium ion transmembrane transport [ISO]
- neuromuscular junction development [IBA]
- positive regulation of calcium ion transport [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of voltage-gated calcium channel activity [IBA]
- synaptic transmission [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.
We describe a cardiac muscle isoform of the voltage-dependent calcium channel alpha1 subunit, which corresponds to the rabbit ortholog of alpha1C-a (Cav1.2a). We also cloned smooth muscle isoforms alpha1C-b (Cav1.2b) and alpha1C-d (Cav1.2d). Differences among these three isoforms lie within the N-terminal region (exon 1A or 1B), the sixth transmembrane segment of domain I (exon 8A or 8B), and the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CACNA1B CACNB2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.907 | BioGRID | 2678384 | |
| CACNB2 CACNA1B | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID