BAIT
DAB1
AI956902, C630028C02Rik, scm, scr, scrambler, yot, RP23-356E21.1
disabled 1
GO Process (20)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- Golgi localization [IMP]
- adult walking behavior [IMP]
- cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [IMP]
- central nervous system development [TAS]
- cerebellum structural organization [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex radially oriented cell migration [IGI, IMP, ISO]
- dendrite development [IGI, IMP]
- intracellular signal transduction [TAS]
- lateral motor column neuron migration [IMP]
- negative regulation of JAK-STAT cascade [IMP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of axonogenesis [IGI, IMP]
- negative regulation of cell adhesion [IMP]
- nervous system development [NAS]
- neuron migration [IGI, IMP, ISO]
- positive regulation of neuron differentiation [IMP]
- positive regulation of protein kinase activity [IGI]
- radial glia guided migration of Purkinje cell [IGI, IMP]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DAB2IP
2310011D08Rik, AI480459, Aip1, mKIAA1743, RP23-4L24.1
disabled 2 interacting protein
GO Process (64)
GO Function (21)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IMP]
- activation of JUN kinase activity [ISO]
- activation of MAPKKK activity [ISO]
- cell motility involved in cerebral cortex radial glia guided migration [IMP]
- cellular protein catabolic process [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to interleukin-1 [IDA, ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cellular response to tumor necrosis factor [IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- layer formation in cerebral cortex [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of G0 to G1 transition [ISO]
- negative regulation of GTPase activity [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Ras GTPase activity [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin catabolic process [ISO]
- negative regulation of endothelial cell migration [IMP, ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of phosphatidylinositol 3-kinase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein phosphorylation [IMP, ISO]
- negative regulation of protein serine/threonine kinase activity [IMP, ISO]
- negative regulation of toll-like receptor 4 signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- neuron projection morphogenesis [IMP]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [IMP, ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras GTPase activity [IBA, ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of dendrite development [IMP]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein catabolic process [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of synapse maturation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of ARF GTPase activity [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of p38MAPK cascade [IMP]
- regulation of protein complex assembly [IMP, ISO]
- tube formation [IMP, ISO]
- vascular endothelial growth factor receptor-2 signaling pathway [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- axon [IDA]
- cerebellar mossy fiber [IDA]
- climbing fiber [IDA]
- cytoplasm [IBA, IDA, ISO]
- endocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [IDA]
- neuronal cell body membrane [IDA]
- parallel fiber [IDA]
- plasma membrane [IDA, ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
The Reelin signaling pathway controls neuronal positioning during mammalian brain development by binding to the very low density lipoprotein receptor and apolipoprotein E receptor-2, and signaling through the intracellular adapter protein Disabled-1 (Dab1). To identify new components in the Reelin signaling pathway, we used a yeast two-hybrid screen to select Dab1-interacting proteins. Here, we report the characterization of a new ... [more]
Brain Res. Mol. Brain Res. Jul. 23, 2003; 115(2);121-9 [Pubmed: 12877983]
Throughput
- Low Throughput
Curated By
- BioGRID