BAIT
BBS1
BBS2L2
Bardet-Biedl syndrome 1
GO Process (6)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CALCA
CALC1, CGRP, CGRP-I, CGRP1, CT, KC
calcitonin-related polypeptide alpha
GO Process (28)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- activation of adenylate cyclase activity [IDA]
- activation of protein kinase activity [IDA]
- cell-cell signaling [TAS]
- cytosolic calcium ion homeostasis [IDA]
- embryo implantation [IDA]
- endothelial cell migration [IDA]
- endothelial cell proliferation [IDA]
- leukocyte cell-cell adhesion [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of blood pressure [IDA]
- negative regulation of bone resorption [IDA]
- negative regulation of calcium ion transport into cytosol [IDA]
- negative regulation of osteoclast differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [IDA]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of interleukin-1 alpha production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of vasodilation [IDA]
- protein phosphorylation [IDA]
- receptor internalization [IDA]
- regulation of blood pressure [NAS]
- vasculature development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel interaction partners of Bardet-Biedl syndrome proteins.
Bardet-Biedl syndrome (BBS) is a rare, developmental disorder characterized by six major symptoms: rod-cone dystrophy, obesity, polydactyly, renal abnormalities, learning difficulties, and hypogonadism. Secondary features include cardiac and hepatic anomalies, metabolic disturbancies, and hearing loss. BBS is genetically heterogeneous with 12 disease genes (BBS1-BBS12) described thus far. Current data suggest a functional disturbance in ciliary function and intraflagellar transport being ... [more]
Cell Motil. Cytoskeleton Feb. 01, 2008; 65(2);143-55 [Pubmed: 18000879]
Throughput
- Low Throughput
Curated By
- BioGRID