BAIT
BBS4
Bardet-Biedl syndrome 4
GO Process (33)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- adult behavior [ISS]
- brain morphogenesis [ISS]
- centrosome organization [IMP]
- cerebral cortex development [ISS]
- cilium assembly [ISS]
- cilium morphogenesis [ISS]
- dendrite development [ISS]
- fat cell differentiation [ISS]
- heart looping [ISS]
- hippocampus development [ISS]
- intracellular transport [ISS]
- maintenance of protein location in nucleus [IGI]
- melanosome transport [ISS]
- metabolic process [IMP]
- microtubule anchoring at centrosome [IMP]
- microtubule cytoskeleton organization [ISS]
- mitotic cytokinesis [IMP]
- negative regulation of appetite by leptin-mediated signaling pathway [ISS]
- neural tube closure [ISS]
- nonmotile primary cilium assembly [ISS]
- photoreceptor cell maintenance [ISS]
- positive regulation of cilium assembly [ISS]
- protein localization to centrosome [IMP]
- protein localization to organelle [ISS]
- regulation of cilium beat frequency involved in ciliary motility [ISS]
- regulation of cytokinesis [IMP]
- regulation of lipid metabolic process [ISS]
- retina homeostasis [ISS]
- retinal rod cell development [ISS]
- sensory perception of smell [ISS]
- sensory processing [TAS]
- spermatid development [ISS]
- striatum development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CALCA
CALC1, CGRP, CGRP-I, CGRP1, CT, KC
calcitonin-related polypeptide alpha
GO Process (28)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- activation of adenylate cyclase activity [IDA]
- activation of protein kinase activity [IDA]
- cell-cell signaling [TAS]
- cytosolic calcium ion homeostasis [IDA]
- embryo implantation [IDA]
- endothelial cell migration [IDA]
- endothelial cell proliferation [IDA]
- leukocyte cell-cell adhesion [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of blood pressure [IDA]
- negative regulation of bone resorption [IDA]
- negative regulation of calcium ion transport into cytosol [IDA]
- negative regulation of osteoclast differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [IDA]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of interleukin-1 alpha production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of vasodilation [IDA]
- protein phosphorylation [IDA]
- receptor internalization [IDA]
- regulation of blood pressure [NAS]
- vasculature development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel interaction partners of Bardet-Biedl syndrome proteins.
Bardet-Biedl syndrome (BBS) is a rare, developmental disorder characterized by six major symptoms: rod-cone dystrophy, obesity, polydactyly, renal abnormalities, learning difficulties, and hypogonadism. Secondary features include cardiac and hepatic anomalies, metabolic disturbancies, and hearing loss. BBS is genetically heterogeneous with 12 disease genes (BBS1-BBS12) described thus far. Current data suggest a functional disturbance in ciliary function and intraflagellar transport being ... [more]
Cell Motil. Cytoskeleton Feb. 01, 2008; 65(2);143-55 [Pubmed: 18000879]
Throughput
- Low Throughput
Curated By
- BioGRID