GIN4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HOF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis.
The conserved NDR-kinase Dbf2 plays a critical role in cytokinesis in budding yeast. Among its cytokinesis related substrates is the F-BAR protein Hof1. Hof1 colocalizes at the cell division site with the septin-complex and, as mitotic exit progresses, moves to the actomyosin ring (AMR). Neither the function of Hof1 at the septin complex nor the mechanism by which Hof1 supports ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide distribution (APO:0000209)
- phenotype: cell shape (APO:0000051)
- phenotype: cell size (APO:0000052)
Additional Notes
- hof1-4E allele, in which four Dbf2 phosphorylation sites have been mutated to glutamic acid to mimic phosphorylation; mislocalization of Shs1-GFP; cells elongated or enlarged
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HOF1 GIN4 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 2377225 | |
GIN4 HOF1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 856721 |
Curated By
- BioGRID