ACVRL1
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- activin receptor signaling pathway [IDA]
- angiogenesis [IMP]
- artery development [ISS]
- blood circulation [IMP]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [TAS]
- blood vessel maturation [TAS]
- blood vessel remodeling [ISS]
- cellular response to BMP stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- endothelial tube morphogenesis [IMP]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [IMP]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of blood vessel endothelial cell migration [IMP]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of focal adhesion assembly [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of chondrocyte differentiation [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of DNA replication [TAS]
- regulation of blood pressure [IMP]
- regulation of blood vessel endothelial cell migration [TAS]
- regulation of endothelial cell proliferation [TAS]
- regulation of transcription, DNA-templated [IMP]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
- venous blood vessel development [ISS]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
ENG
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- artery morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- cell motility [IMP]
- central nervous system vasculogenesis [IMP]
- chronological cell aging [IEP]
- detection of hypoxia [IDA]
- extracellular matrix disassembly [IMP]
- heart looping [ISS]
- intracellular signal transduction [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- patterning of blood vessels [ISS]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of systemic arterial blood pressure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell adhesion [TAS]
- regulation of cell proliferation [TAS]
- regulation of phosphorylation [TAS]
- regulation of transcription, DNA-templated [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to hypoxia [IDA]
- smooth muscle tissue development [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- vasculogenesis [IMP]
- venous blood vessel morphogenesis [ISS]
- wound healing [IMP]
Gene Ontology Molecular Function- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.
Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, and mutations in either endoglin or ALK-1 genes are responsible for the vascular dysplasia known as hereditary hemorrhagic telangiectasia. Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ENG ACVRL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID