TNKS
Gene Ontology Biological Process
- mitotic spindle organization [TAS]
- negative regulation of DNA binding [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of telomere maintenance via telomerase [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein ADP-ribosylation [IDA]
- protein auto-ADP-ribosylation [IDA]
- protein localization to chromosome, telomeric region [IMP]
- protein poly-ADP-ribosylation [IDA]
- protein polyubiquitination [IDA]
- regulation of telomere maintenance via telomerase [IC]
- spindle assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TNKS
Gene Ontology Biological Process
- mitotic spindle organization [TAS]
- negative regulation of DNA binding [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of telomere maintenance via telomerase [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein ADP-ribosylation [IDA]
- protein auto-ADP-ribosylation [IDA]
- protein localization to chromosome, telomeric region [IMP]
- protein poly-ADP-ribosylation [IDA]
- protein polyubiquitination [IDA]
- regulation of telomere maintenance via telomerase [IC]
- spindle assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ribosylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
Telomere length in humans is partly controlled by a feedback mechanism in which telomere elongation by telomerase is limited by the accumulation of the TRF1 complex at chromosome ends. TRF1 itself can be inhibited by the poly(ADP-ribose) polymerase (PARP) activity of its interacting partner tankyrase 1, which abolishes its DNA binding activity in vitro and removes the TRF1 complex from ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNKS TNKS | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 3556111 | |
| TNKS TNKS | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1255295 | |
| TNKS TNKS | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 303925 |
Curated By
- BioGRID