CACNG2
Gene Ontology Biological Process
- calcium ion transmembrane transport [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- neurological system process [IMP]
- neuromuscular junction development [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IMP]
- transmission of nerve impulse [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIA1
Gene Ontology Biological Process
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- long term synaptic depression [IGI]
- long-term memory [IMP, ISO]
- neuronal action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor internalization [IMP, ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to toxic substance [ISO]
- synaptic transmission [IGI]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- axonal spine [IDA]
- cell surface [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendrite membrane [IDA]
- dendritic shaft [ISO]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- ionotropic glutamate receptor complex [IDA]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- protein complex [ISO]
- recycling endosome [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular constituents of neuronal AMPA receptors.
Dynamic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) underlies aspects of synaptic plasticity. Although numerous AMPAR-interacting proteins have been identified, their quantitative and relative contributions to native AMPAR complexes remain unclear. Here, we quantitated protein interactions with neuronal AMPARs by immunoprecipitation from brain extracts. We found that stargazin-like transmembrane AMPAR regulatory proteins (TARPs) copurified with neuronal AMPARs, but we found negligible ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIA1 CACNG2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.3795 | BioGRID | 3498746 |
Curated By
- BioGRID