MUSK
Gene Ontology Biological Process
- long-term synaptic potentiation [ISO]
- memory [ISO]
- negative regulation of gene expression [ISO]
- neuromuscular junction development [IGI]
- peptidyl-tyrosine phosphorylation [ISO, TAS]
- positive regulation of gene expression [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein geranylgeranylation [IMP]
- positive regulation of protein phosphorylation [IMP, ISO]
- positive regulation of synaptic growth at neuromuscular junction [ISO]
- positive regulation of synaptic transmission, cholinergic [ISO]
- protein autophosphorylation [ISO]
- receptor clustering [IGI, IMP, ISO]
- regulation of synaptic growth at neuromuscular junction [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to electrical stimulus [ISO]
- signal transduction [TAS]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MUSK
Gene Ontology Biological Process
- long-term synaptic potentiation [ISO]
- memory [ISO]
- negative regulation of gene expression [ISO]
- neuromuscular junction development [IGI]
- peptidyl-tyrosine phosphorylation [ISO, TAS]
- positive regulation of gene expression [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein geranylgeranylation [IMP]
- positive regulation of protein phosphorylation [IMP, ISO]
- positive regulation of synaptic growth at neuromuscular junction [ISO]
- positive regulation of synaptic transmission, cholinergic [ISO]
- protein autophosphorylation [ISO]
- receptor clustering [IGI, IMP, ISO]
- regulation of synaptic growth at neuromuscular junction [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to electrical stimulus [ISO]
- signal transduction [TAS]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation ... [more]
Throughput
- Low Throughput
Additional Notes
- Dok-7 induces autophosphorylation of MuSK
Curated By
- BioGRID