MUSK
Gene Ontology Biological Process
- long-term synaptic potentiation [ISO]
- memory [ISO]
- negative regulation of gene expression [ISO]
- neuromuscular junction development [IGI]
- peptidyl-tyrosine phosphorylation [ISO, TAS]
- positive regulation of gene expression [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein geranylgeranylation [IMP]
- positive regulation of protein phosphorylation [IMP, ISO]
- positive regulation of synaptic growth at neuromuscular junction [ISO]
- positive regulation of synaptic transmission, cholinergic [ISO]
- protein autophosphorylation [ISO]
- receptor clustering [IGI, IMP, ISO]
- regulation of synaptic growth at neuromuscular junction [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to electrical stimulus [ISO]
- signal transduction [TAS]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DOK7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID