BAIT
KCNMA1
BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1, RP11-443A13.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- micturition [IDA]
- negative regulation of cell volume [IDA]
- positive regulation of apoptotic process [IMP]
- potassium ion transmembrane transport [IBA, IDA]
- potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- response to calcium ion [IDA]
- response to carbon monoxide [IDA, IMP]
- response to hypoxia [IDA]
- response to osmotic stress [IDA]
- smooth muscle contraction involved in micturition [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACTG2
ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM
actin, gamma 2, smooth muscle, enteric
GO Process (1)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current.
Multiple cell-signaling pathways converge to modulate large-conductance, voltage- and Ca2+-sensitive K+ channel (maxi-K channel) activity and buffer cell excitability in human myometrial smooth muscle cells (hMSMCs). Recent evidence indicates that maxi-K channel proteins can target to membrane microdomains; however, their association with other proteins within these macromolecular complexes has not been elucidated. Biochemical isolation of detergent-resistant membrane fractions from human ... [more]
Am. J. Physiol., Cell Physiol. Jul. 01, 2005; 289(1);C49-57 [Pubmed: 15703204]
Throughput
- Low Throughput
Ontology Terms
- tissue: myometrium (BTO:0000907)
Additional Notes
- interaction detected in myometrium at non-pregnant and late pregnant
Curated By
- BioGRID