TRIP12
Gene Ontology Biological Process
Gene Ontology Molecular Function
SOX6
Gene Ontology Biological Process
- astrocyte differentiation [ISO]
- cardiac muscle cell differentiation [IDA]
- cartilage development [IGI]
- cell fate commitment [IGI]
- cell morphogenesis [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- erythrocyte development [IMP]
- erythrocyte differentiation [IMP]
- gene silencing [IMP]
- hemopoiesis [IMP]
- in utero embryonic development [IMP]
- muscle cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- oligodendrocyte cell fate specification [IMP]
- oligodendrocyte differentiation [IMP]
- positive regulation of cartilage development [ISO]
- positive regulation of chondrocyte differentiation [IDA, ISO]
- positive regulation of mesenchymal stem cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IMP]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.
A sophisticated level of coordinated gene expression is necessary for skeletal muscle fibers to obtain their unique functional identities. We have previously shown that the transcription factor Sox6 plays an essential role in coordinating muscle fiber type differentiation by acting as a transcriptional suppressor of slow fiber-specific genes. Currently, mechanisms regulating the activity of Sox6 in skeletal muscle and how ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRIP12 SOX6 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.941 | BioGRID | 2686673 |
Curated By
- BioGRID