BAIT

BAI1

GDAIF
brain-specific angiogenesis inhibitor 1
Homo sapiens
PREY

MAGI1

AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3, RP11-88H12.2
membrane associated guanylate kinase, WW and PDZ domain containing 1
Human Papilloma Virus (HPV) Project
GO Process (4)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Brain-Specific Angiogenesis Inhibitor-1 Signaling, Regulation and Enrichment in the Postsynaptic Density.

Stephenson JR, Paavola KJ, Schaefer SA, Kaur B, Van Meir EG, Hall RA

Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor (GPCR) that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We found that over-expression of BAI1 results in activation of the Rho pathway via a Galpha12/13-dependent mechanism, with truncation of the BAI1 N-terminus (NT) resulting in a dramatic enhancement in receptor signaling. This constitutive activity of the truncated ... [more]

J. Biol. Chem. Jun. 19, 2013; 0(0); [Pubmed: 23782696]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
BAI1 MAGI1
Reconstituted Complex
Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Low-BioGRID
-
BAI1 MAGI1
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID