BAIT
ATF6B
CREB-RP, CREBL1, G13, DADB-220I18.4
activating transcription factor 6 beta
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XBP1
TREB5, XBP-1, XBP2
X-box binding protein 1
GO Process (60)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- adipose tissue development [ISS]
- angiogenesis [ISS]
- cell growth [IDA]
- cellular protein metabolic process [TAS]
- cellular response to amino acid stimulus [ISS]
- cellular response to fluid shear stress [IDA]
- cellular response to fructose stimulus [ISS]
- cellular response to glucose starvation [ISS]
- cellular response to glucose stimulus [ISS]
- cellular response to insulin stimulus [ISS]
- cellular response to interleukin-4 [ISS]
- cellular response to laminar fluid shear stress [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to nutrient [ISS]
- cellular response to oxidative stress [IDA]
- cellular response to peptide hormone stimulus [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- cellular triglyceride homeostasis [ISS]
- cholesterol homeostasis [ISS]
- endoplasmic reticulum unfolded protein response [ISS, TAS]
- endothelial cell proliferation [IDA]
- fatty acid homeostasis [ISS]
- immune response [TAS]
- liver development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of endoplasmic reticulum unfolded protein response [IDA]
- negative regulation of myotube differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuron development [ISS]
- phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of B cell differentiation [IDA]
- positive regulation of MHC class II biosynthetic process [IMP]
- positive regulation of T cell differentiation [IDA]
- positive regulation of TOR signaling [IMP]
- positive regulation of autophagy [IDA]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of fat cell differentiation [ISS]
- positive regulation of hepatocyte proliferation [ISS]
- positive regulation of histone methylation [IDA]
- positive regulation of immunoglobulin production [IDA]
- positive regulation of immunoglobulin secretion [ISS]
- positive regulation of interleukin-6 secretion [ISS]
- positive regulation of lactation [ISS]
- positive regulation of plasma cell differentiation [IDA]
- positive regulation of protein acetylation [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA, ISS]
- protein destabilization [IDA, IMP]
- regulation of protein stability [IDA]
- response to endoplasmic reticulum stress [IDA]
- response to insulin-like growth factor stimulus [ISS]
- sterol homeostasis [ISS]
- transcription from RNA polymerase II promoter [ISS]
- ubiquitin-dependent protein catabolic process [ISS]
- vascular endothelial growth factor receptor signaling pathway [IDA]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- DNA binding [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [ISS]
- enhancer sequence-specific DNA binding [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
Differences in biomolecular sequence and function underlie dramatic ranges of appearance and behavior among species. We studied the basic region-leucine zipper (bZIP) transcription factors and quantified bZIP dimerization networks for five metazoan and two single-cell species, measuring interactions in vitro for 2891 protein pairs. Metazoans have a higher proportion of heteromeric bZIP interactions and more network complexity than the single-cell ... [more]
Science May. 10, 2013; 340(6133);730-4 [Pubmed: 23661758]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| XBP1 ATF6B | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | High | - | BioGRID | - |
Curated By
- BioGRID