ACVR2B
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [IMP]
- artery development [ISS]
- blood vessel remodeling [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- regulation of transcription, DNA-templated [IDA]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INHBA
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [IDA]
- cell cycle arrest [IDA]
- cell development [IBA]
- cell differentiation [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [TAS]
- defense response [TAS]
- endodermal cell differentiation [IDA]
- erythrocyte differentiation [NAS]
- extrinsic apoptotic signaling pathway [IDA]
- eyelid development in camera-type eye [ISS]
- hair follicle development [IGI]
- hematopoietic progenitor cell differentiation [IDA]
- hemoglobin biosynthetic process [IDA]
- male gonad development [IGI]
- negative regulation of B cell differentiation [TAS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of follicle-stimulating hormone secretion [NAS]
- negative regulation of interferon-gamma biosynthetic process [TAS]
- negative regulation of macrophage differentiation [TAS]
- negative regulation of phosphorylation [TAS]
- nervous system development [NAS]
- odontogenesis [IGI]
- ovarian follicle development [IGI, NAS]
- palate development [IGI]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- positive regulation of follicle-stimulating hormone secretion [TAS]
- positive regulation of ovulation [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- progesterone secretion [IGI]
- regulation of MAPK cascade [IBA]
- regulation of follicle-stimulating hormone secretion [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGF beta and activin type II receptors, act as type I receptors for these factors. TSR-I is ... [more]
Throughput
- Low Throughput
Additional Notes
- ACVR1 can only bind Activin in the presence of transfected ACVR2B
- ACVRL1 can only bind Activin in the presence of transfected ACVR2B
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INHBA ACVR2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ACVR2B INHBA | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID