PDS5
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [IMP]
- cellular protein localization [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome passenger complex localization to kinetochore [IMP]
- mitotic sister chromatid cohesion [IGI]
- mitotic sister chromatid segregation [IMP]
- protein localization to chromosome, centromeric region [IMP]
- protein localization to kinetochore [IMP]
- regulation of histone H3-T3 phosphorylation [IDA]
- regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SGO2
Gene Ontology Biological Process
Gene Ontology Cellular Component
Dosage Growth Defect
A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
Publication
Two histone marks establish the inner centromere and chromosome bi-orientation.
For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex (CPC) including Aurora B and survivin must be localized at the center of paired kinetochores, at the site called the inner centromere. It is largely unknown what defines the inner centromere and how the CPC is targeted to this site. Here, we show that the phosphorylation of histone H3-threonine ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PDS5 SGO2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.5209 | BioGRID | 522414 | |
SGO2 PDS5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.8446 | BioGRID | 769689 | |
SGO2 PDS5 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | PomBase | - |