ECE1
Gene Ontology Biological Process
- bradykinin catabolic process [IDA]
- calcitonin catabolic process [IDA]
- ear development [IMP]
- embryonic digit morphogenesis [IMP]
- endothelin maturation [IDA]
- heart development [IMP]
- hormone catabolic process [IDA]
- peptide hormone processing [IDA]
- positive regulation of receptor recycling [IMP]
- protein processing [IDA]
- regulation of systemic arterial blood pressure by endothelin [IC]
- regulation of vasoconstriction [IC]
- substance P catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Weibel-Palade body [IDA]
- early endosome [IDA]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IDA]
- intrinsic component of endosome membrane [TAS]
- lysosomal membrane [IDA]
- membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- vesicle [ISS]
CALCA
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- activation of adenylate cyclase activity [IDA]
- activation of protein kinase activity [IDA]
- cell-cell signaling [TAS]
- cytosolic calcium ion homeostasis [IDA]
- embryo implantation [IDA]
- endothelial cell migration [IDA]
- endothelial cell proliferation [IDA]
- leukocyte cell-cell adhesion [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of blood pressure [IDA]
- negative regulation of bone resorption [IDA]
- negative regulation of calcium ion transport into cytosol [IDA]
- negative regulation of osteoclast differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [IDA]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of interleukin-1 alpha production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of vasodilation [IDA]
- protein phosphorylation [IDA]
- receptor internalization [IDA]
- regulation of blood pressure [NAS]
- vasculature development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
Although cell surface metalloendopeptidases degrade neuropeptides in the extracellular fluid to terminate signaling, the function of peptidases in endosomes is unclear. We report that isoforms of endothelin-converting enzyme-1 (ECE-1a-d) are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors. Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), beta-arrestin2, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID