BAIT

SNTA1

LQT12, SNT1, TACIP1, dJ1187J4.5
syntrophin, alpha 1
Homo sapiens
PREY

ABCC4

MOAT-B, MOATB, MRP4, RP11-74A12.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Glioblastoma Project
GO Process (5)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.

Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized at apical cell membranes and exists in macromolecular complexes with a variety of signaling and transporter molecules. Here, we report that the multidrug resistance protein 4 (MRP4), a cAMP transporter, functionally and physically associates with CFTR. Adenosine-stimulated CFTR-mediated chloride currents are potentiated by MRP4 inhibition, and this potentiation ... [more]

Cell Nov. 30, 2007; 131(5);940-51 [Pubmed: 18045536]

Throughput

  • Low Throughput

Curated By

  • BioGRID