BAIT
MAPK15
ERK7, ERK8
mitogen-activated protein kinase 15
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GABARAP
RP23-172M21.5
gamma-aminobutyric acid receptor associated protein
GO Process (7)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin cytoskeleton [IDA]
- autophagic vacuole [ISO]
- autophagic vacuole membrane [IBA, ISO]
- axoneme [IDA]
- cell body [ISO]
- cytosol [IBA]
- extrinsic component of membrane [IBA]
- lysosome [IDA]
- microtubule associated complex [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- pre-autophagosomal structure [IBA]
- smooth endoplasmic reticulum [IDA]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress. Although several genes belonging to the core molecular machinery involved in autophagosome formation have been discovered, relatively little is known about the nature of signaling networks controlling autophagy upon intracellular or extracellular stimuli. We ... [more]
Autophagy Dec. 01, 2012; 8(12);1724-40 [Pubmed: 22948227]
Throughput
- Low Throughput
Curated By
- BioGRID